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Their upregulation may have potential benefits in mood and stress management [3, 4, 5]

doi: 10.7759/cureus.53221 38

This activation not only helps in neutralizing oxidative stress but also promotes cellular resilience against more significant stressors, thereby contributing to cancer chemoprevention and overall health maintenance

Thus, the -glutamyl cycle, apart from explaining the synthesis and degradation of glutathione, may serve as a generator of signals to activate amino acid transport into cells (2, 75)

The use of L-asparaginase significantly enhances the effectiveness of immune checkpoint blockade therapy by improving CD8+ T cell adaptability